Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP coumarin 68 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)

68 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

193 Purity (HPLC) >= 95% Solubility DMSO

366 Purity (HPLC) >= 95% Solubility DMSO

It reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT)

Product Name Thalidomide-C4-OH Synonyms Thalidomide-4'-C4-OH CAS Number n/a Related CAS Molecular Formula C17H18N2O5 Molecular Weight 330

Mal-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP coumarin 68 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating leaving group, enabling efficient and selective conjugation of the payload